RNAi Screening Libraries
HORIZON DISCOVERY BIOSCIENCES LIMITED CRISPRI LENTIVIRAL SGRNA NON
NC3666507 CRISPRI LENTIVIRAL SGRNA NON
Cayman Chemical Tol-LIke Receptr 8 Monclon 1ea
Antigen: peptide from human TLR8 within the region of amino acids 750-850 • Host: mouse, clone 44C143 • Cross Reactivity: (+) human and mouse TLR8 • Application(s): FC (intracellular and cell surface), IHC (paraffin-embedded sections), and WB • TLRs mediate innate immunity that is essential for microbial recognition. The TLR8 gene contains three exons, two of which have coding function.
INTACT GENOMICS INC sgRNA Synthesis Kit for Cas12a Nuclease 10 Reactions (20 µl RXN Volume)
IG sgRNA Synthesis Kits are a perfect choice for a variety of sgRNA synthesis needs. Below is a sampling of some of the key benefits. IG sgRNA Synthesis Kit includes everything but your targeting oligo (all buffers, enzymes, scaffolds) User simply needs to provide the oligo for your target—Must be 55 base pairs and generated using the template design in this manual. Rapid Workflow (Less than 1 hour) Scalable Yield (just 1 reaction for all the sgRNA you need) Customer support – our team is available to aid with your success.IG sgRNA Synthesis Kits contains the items below. Store all components at -20°C. IG sgRNA Enzyme Mix (10X) IG sgRNA Reaction Mix, S. pyogenes (4X) DNase I (RNase-free, 2 Units/uL) IG sgRNA Control Oligo, S. pyogenes (1 uM) Dithiothreitol (DTT, 0.2 M) NTPs mix (25 mM)
INTACT GENOMICS INC sgRNA Synthesis Kit for Cas12a Nuclease 10 Reactions (100 µl RXN Volume)
IG sgRNA Synthesis Kits are a perfect choice for a variety of sgRNA synthesis needs. Below is a sampling of some of the key benefits. IG sgRNA Synthesis Kit includes everything but your targeting oligo (all buffers, enzymes, scaffolds) User simply needs to provide the oligo for your target—Must be 55 base pairs and generated using the template design in this manual. Rapid Workflow (Less than 1 hour) Scalable Yield (just 1 reaction for all the sgRNA you need) Customer support – our team is available to aid with your success.IG sgRNA Synthesis Kits contains the items below. Store all components at -20°C. IG sgRNA Enzyme Mix (10X) IG sgRNA Reaction Mix, S. pyogenes (4X) DNase I (RNase-free, 2 Units/uL) IG sgRNA Control Oligo, S. pyogenes (1 uM) Dithiothreitol (DTT, 0.2 M) NTPs mix (25 mM)
HORIZON DISCOVERY BIOSCIENCES LIMITED SV INDUCIBLE HU PAX8 SHRNA
NC3822534 SV INDUCIBLE HU PAX8 SHRNA
Cayman Chemical TolLIke Receptr 12 Polyclo 1ea
Antigen: mouse TLR12 amino acids 911-926 • Host: rabbit • Cross Reactivity: (+) mouse and rat TLR12 • Application(s): FC (intracellular) and WB • TLR12 displays a distinct pattern of expression in macrophages, liver, kidney, and bladder epithelial cells. TLR12 does not respond to known TLR ligands.
Cayman Chemical EP Receptr asy Prostaglnd 20uL
An ionizable cationic lipid (pKa 6.39) has been used in the generation of LNPs for siRNA delivery in vitro and in vivo LNPs containing O12-D3-I3 and encapsulating ferrocene and siRNA targeting Nrf2 or system xc- cystine/glutamate transporter decrease viability of HepG2 cells LNPs containing O12-D3-I3 and an mRNA reporter selectively accumulate in the tumor and liver over the lungs kidneys spleen and heart in mice LNPs containing O12-D3-I3 and encapsulating ferrocene and siRNA targeting Nrf2 or system xc- cystine/glutamate transporter reduce tumor growth and volume in an MCF-7 breast cancer mouse xenograft model LNPs containing O12-D3-I3 and encapsulating siRNA targeting Factor VII decrease hepatocyte Factor VII mRNA levels in mice
Cayman Chemical Dog Pregn X Receptr Repor 96
dPXR Reporter Cells are prepared using INDIGO’s proprietary CryoMite™ process. This cryo-preservation method yields exceptional cell viability post-thaw, and provides the convenience of immediately dispensing healthy, division-competent reporter cells into assay plates. There is no need for cumbersome intermediate treatment steps such as spin-and-rinse of cells, viability determinations, or cell titer adjustments prior to assay setup.[INDIGO Catalog Nos. D07001-32, D07001]
Cayman Chemical TrnsfRrIn Receptr ProteIn 50uL
A phenylethanoid glycoside selectively inhibits aldose reductase over maltase and sucrase (IC50s 0.071 300 and 277 UM respectively for the rat enzymes) scavenges superoxide radicals in a cell-free assay and inhibits AAPH-induced hemolysis in isolated rat red blood cells decreases glutamate-induced cytotoxicity in primary rat cortical neurons at 0.1 1 and 10 UM protects primary mouse hepatocytes against D-galactosamine-induced cytotoxicity (IC50 4.8 Ug/ml) prevents decreases in bone strength in ovariectomized mice from 10-40 mg/kg
Cayman Chemical EP4 Receptr ntagonIst 1 10mg
An EP4 receptor antagonist (IC50 = 6.1 nm in a calcium flux assay); selective for EP4 over EP1, EP2, and EP3 receptors (IC50s = >10,000 nM for all); reverses PGE2-induced ERK phosphorylation in EP4-expressing CHO cells and decreases GM-CSF-induced expression of Il1b, Il4ra, Il6, Arg1, Cox2, and Il10 in RAW 264.7 cells at 10 µM; reduces tumor volume and increases infiltration of CD8+ T cells into tumors in a murine colon carcinoma model at 50 and 150 mg/kg once per day
HORIZON DISCOVERY BIOSCIENCES LIMITED HUMAN PRDM1 SYNTHETIC SGRNA SE
NC3841492 HUMAN PRDM1 SYNTHETIC SGRNA SE
HORIZON DISCOVERY BIOSCIENCES LIMITED PIN-POINT SYNTHETIC SGRNA VALI
NC3867373 PIN-POINT SYNTHETIC SGRNA VALI
Cayman Chemical Humn RetInoIc ACD Receptr 384
RARγ Reporter Cells are prepared using INDIGO’s proprietary CryoMite™ process. This cryo-preservation method yields high cell viability post-thaw, and provides the convenience of immediately dispensing healthy, division-competent reporter cells into assay plates. There is no need for intermediate spin-and-wash steps, viability determinations, or cell titer adjustments. [INDIGO Catalog Nos. IB02001-32, IB02001, IB02002]